GW-501516 – The Big Question

GW-501516 was studied as a drug by GlaxoSmithKline. It is a Peroxisome proliferator-activated receptor delta (PPARδ) receptor antagonist and was found to cause cancer in rats. Since then, further development was stopped by GlaxoSmithKline. It was seen as a possible cure to for cardiovascular disease, obesity, dyslipidemia, and diabetes. It was found out to have a synergistic effect when combined with AICAR, or AICA ribonucleutide; in animal studies, the resulting combination was shown as having an interesting effect – it remarkably increases exercise endurance.

GW501516GW-501516 was first discovered in a collaborative research between Ligand Pharmaceuticals and GSK which kicked off in 1992. The first phase of trials, in 2000, was for the treatment of hyperlidimia. It was followed by phase I/II in 2002. Ligand Pharmaceuticals earned $1 million payment because GSK wanted to continue development of the compound. GSK had done two phase II clinical studies before ceasing development in 2007.

The Peroxisome proliferator-activated receptors present in GW-501516 are said to have an effect on nuclear hormone receptors linked to glucose and lipid metabolism. It works at the gene level and impacts the metabolism of the muscle. Based on this, GW-501516 is not in the same category with restricted drugs that is akin to steroids because of the way the drug works in the body.

Tests involving GW-501516 was first conducted on mice. This resulted in increased muscle mass, decreased fat mass build-up, and increased glucose tolerance. Later on, more studies were done that demonstrated that there was a potential of developing a kind of tumor. There were three initial studies done by GSK on GW-501516 – two phase ones and a single phase two. The first phase I trial was brought to an end for reasons not explicitly stated. The second phase I trial was completed, as well as the phase II trial. In Australia, the use of GW-501516 was assessed in the treatment of high blood cholesterol; this was marked as the fourth phase.

A lot of people buy GW-501516, but the World Anti-Doping Agency, or WADA, has been warning them against the purchase of such drugs. WADA has been the leader in the charge opposing GW-501516 and put out an advisory in March 2013 highlighting the probable health risks that can be caused by GW-501516. This was more aimed towards those who buy GW-501516 in the black market. The advisory also sought to serve as an eye-opener to the athletes who buy and use GW-501516 as an endurance booster. Since 2009, WADA’s prohibited drug list has had peroxisome proliferator-activated receptors on it. PPARs have also been prohibited from in and out of competition by the Australian Sports Anti-Doping Authority.

WADA was not the only one taking action against GW-501516; the NCAA has also thrown itself into the mix and has stated that it would work together with the Committee on Competitive Safeguards and Medical Aspects of Sport to discern where the drug falls on their banned substances list. These organizations know for sure that GW-501516 is not easily obtained, meaning that the black market is the only place where they can be purchased and that the drug will be in short supply sooner or later. They also hope that that the increased price for the drug would discourage people that buy GW-501516.

In spite of the fact that governing bodies such as WADA and NCAA have issued warnings regarding GW-501516 and the still unclear possible health risks that may exist, there are still some who continue to buy GW-501516. It is no secret that there has been a history of illegal drugs and performance enhancing drugs on the black market and GW-501516 is up there. The question is though, should the substance really be treated with such negativity despite having proven benefits and unconfirmed downsides?

One Way to Avoid a Foreclosure is by Negotiating for a Loan Modification

A bad economy can have a devastating effect on the value of a home, more so after the market has peaked as what happened during the recent real estate market collapse. When home values are less than the original mortgage amount, which is what is happening in Long Island, this becomes known as an underwater mortgage. Exacerbated by a job loss or a medical emergency, an underwater mortgage can make many homeowners vulnerable to foreclosure.

A Long Island foreclosure lawyer can help a troubled homeowner facing foreclosure by exploring options in loan modification. A loan modification is a permanent restructuring of the mortgage where one or more of the terms of a borrower's loan are changed to provide a more affordable payment. With a loan modification, the goal of the borrower is to reduce the monthly payments but this will result in a higher overall mortgage amount. This can be accomplished by a reduction in interest, conversion of a variable interest rate to a fixed interest rate, or extension of the length of the term.

Long Island foreclosure lawyerTo be eligible for a loan modification, the borrower has to prove that current mortgage payments cannot be made due to a financial hardship. The borrower must also complete a trial period to demonstrate that the new monthly amount is workable. To evaluate an application, the lender will require documentation in the form of proof of income, a financial statement, bank statements, most recent tax returns, and a hardship letter that a Long Island foreclosure lawyer can assist in providing to the lender on behalf of the borrower.

Under the Real Estate Settlement and Procedures Act, a homeowner may exercise legal rights with respect to loan modification. If a home was refinanced and the current mortgage was completed within the last three years, the homeowner may rescind the mortgage and annul the finance charges upon failure by the lender to furnish expedient announcements to the homeowner. A Long Island foreclosure lawyer should be consulted about this matter.

In more drastic circumstances, a forbearance agreement may offer temporary relief for borrowers. The lender may consent to a reduction or suspension of mortgage payments for a particular duration and abstain from further foreclosure proceedings during the forbearance period. In return, the borrower will agree to continue with the payment at the end of the forbearance period, including additional amounts covering missed payments to make the account current. A Long Island foreclosure lawyer will also ensure that payments regarding the principal, interest, taxes, and insurance are all included in the forbearance agreement.

The borrower must be reminded that a forbearance agreement is only an interim respite due to a momentary hardship that has caused a lapse in mortgage payments. Nevertheless, it allows avoidance of foreclosure until such time that the borrower’s standing improves. In some cases, depending on the ability of the Long Island foreclosure lawyer, the lender may be lenient enough as to extend the forbearance period if the adversity experienced by the borrower is prolonged.

On the other hand, a repayment plan allows a borrower to make reduced mortgage payments over a specified length of time with the end in view of making the account current after the given period. The idea is to spread the past due amount over several months so that payment is easily affordable but consistent with the overdue amount added to each of the monthly payments. The length of payment will vary depending on each borrower’s capacity to pay but the goal is for the mortgage to eventually become current. The amount of payments and duration of the repayment plan can be influenced by the competence of the lawyer handling the negotiations.

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Materials Used In Making ID Lanyards

Why is it important for you to know the materials used in making lanyards?

ID lanyards have become an item that states a company’s identity and the wearer’s personality. As the wearer, your lanyard carries the name of the organization you belong to. It also provides security personnel an idea of the company or institution you are affiliated with.

Others have used ID lanyards for their marketing strategy too. Most companies nowadays have used these during events–customizing lanyards to display their company name or brand. It has been used as giveaways or price items.

So why exactly is it important to know the materials used?

This is because each lanyard material is made specifically for wearers working in a certain environment.

ID lanyards

As ID lanyards are more used these days, it is best to also make sure that the ones you will be wearing and giving away fit the environment where it will be worn in most. First, it should be durable. If you are working with water around you, like in waterparks or ice plants, it is best to have lanyards made with materials that are good with water. If you are working as a coach, it is best to use one that is good with moisture. Second, knowing the materials used in your lanyard will help you maintain it. You can easily wash without worrying about watermarks, and so on. Third, you don’t have to worry about prints getting washed away or fading fast if you are using lanyards for promotion. There are materials used for such especially if you are having your company’s logo printed.

Materials Used

If you want to know the best ID lanyards you can use for a specific event, especially the materials it should be made of, here’s a list for you. Below are six of the most commonly used materials used in making lanyards.

Polyesters

Polyesters are the most common material used. Natural polyesters and some synthetic ones are biodegradable. While synthetic version of these does not provide a natural feel to the skin, it has certain advantage such as wrinkle resistance, durability and high color retention.

If you are offering lanyards for your business, customizing it is important. Polyester lanyards will do nicely for this job due to its resistance to color fading plus you can easily print your logo and company name.

Satin

The satin fabric is usually glossy on its surface but dull on the back. Due to its luster, it has become a widely used fabric for apparels like baseball jackets, athletic shorts, nightgowns, blouses and so on. This has also been used in making bed sheets due to its high number of floats.

Silk

Silk is one of the most highly used fabrics. It was first developed in China by Empress Leizu and has since then emerged as one of the most fashionable fabric to use. Silk is developed by using cocoons of silk moths.

Silk is used in making gowns and evening wear. It is also used in traditional clothing like in India and Mediterranean.

Braided paracord

The paracord is used by military. They are usually used for parachute suspension and for other safety tools. Using it for ID lanyards is another thing. While people pictures it as too large to be hung around the neck, what is really used is the braided paracord within. Yes, there are other cords inside the paracord we see and that is what’s used for lanyard making.

Selecting the Material

Before you buy an ID lanyard, it is best to check for the materials. Choose one that can help you print your organization or brand and is resistant to fading. You should also choose something light and moisture resistant or something that is light and dries easily (of course, depending on the environment it will be displayed and used). Selecting the material for your lanyard will help your promotion and use easier.

Golf Apparel 101: A Guide on Buying Golf Shirts

If you play golf, you can buy your golf apparel at your local sporting goods store or at a specialty golfing store. You can also search the department store for affordable clothes and accessories. You can even shop online. Nowadays, many people choose to shop online because it is easy, convenient, and time-efficient. A lot of brick-and-mortar store owners also have their own websites to attract more customers.

Golf ApparelWhen it comes to buying golf shirts, see to it that you check out different materials. Cotton, for instance, is one of the most common choices. Cotton shirts are light, breathable, and stretchable. They are also available in a wide variety of colors. Many golfers prefer to wear cotton golf apparel both outdoors and indoors because it lets the air circulate around their skin. Cotton shirts are especially ideal on hot summer days as well as days when the weather seems unpredictable.

You can find different types of cotton, such as mercerized cotton and pima cotton. Mercerized cotton is made by removing stray fibers from the cotton thread before it is woven. This makes it smoother, shinier, and stronger than regular cotton. It is also more comfortable. Pima cotton, on the other hand, is high quality cotton that is admired for its long fibers. It is soft, dense, and warm.

Performance fabrics, such as polyester microfiber, are popular materials for golf shirts too. They are lighter than one hundred percent cotton. They are known for their good fit and moisture-wicking properties. You can buy a performance golf shirt that is made with a combination of cotton and polyester. Golf shirts like this can make you more flexible in the golf course. They may also feature antibacterial treatments to protect you against bacteria.

If you need protection against harsh weather conditions, you should wear golf apparel made with engineered fabrics. These golf shirts can protect you against the wind. Their versatility can help you retain your focus on the game even during harsh weather conditions. They will not make you uncomfortable even when playing golf in the rain.

Golf shirts made with cotton blends are generally resistant to stains and are crease proof. They are also less expensive than shirts made with one hundred percent cotton. However, unlike the shirts made with pure cotton, they do not have a high tensile strength and hypoallergenic properties because they have been exposed to harsh chemicals. They also contain synthetic fibers.

Do not forget to consider the weight of your shirt and other golf apparel. Weight generally refers to the thickness of the fabric. Golf shirts usually weigh around four to eight and a half ounces. As mentioned above, shirts that are made with blended or performance fabrics tend to be more lightweight than shirts made with one hundred percent cotton. If you want something more flexible, you should go for lightweight shirts. On the other hand, if you prefer something more suitable for cold weather, you should go for heavier shirts.

Then again, no matter what type of golf shirt you get, you have to make sure that you know what a good fit is. For instance, when you wear a crewneck sweater over your golf shirt, make sure that you keep the collar in for a cleaner look. With this being said, it is imperative that you wear a shirt with a collar. T-shirts are generally not allowed on golf courses.

Likewise, you should keep your shirt tucked in unless you want to look sloppy. If you want to wear patterned golf apparel, see to it that the patterns do not dominate both your shirt and pants. In general, a plain shirt goes best with bold-colored pants, and vice versa. If you are wearing a belt, you should match it with your shirt instead of your shoes.